Translational Strategy

The Challenge:

A small, highly virtualized biotech had identified an attractive target in fibrotic diseases and needed a translational strategy to generate clinical data that enables data-driven decision-making for future development as well as increases the asset value. 

The Action:

TherapeutAix was contracted to define the translational approach scoping elements ranging from in vitro / in vivo mechanistic bridging through to disease models with translational integrity. 

We have reviewed the literature and revisited earlier internal decision matrixes enabling prioritization between different fibrotic diseases. A broad translational plan was outlined, comprising several distinct and partly overlapping trajectories. Several sets of in vitro, in vivo, and clinical translational study concepts were created that emphasized different aspects of translational confidence (e.g., mechanistic vs antifibrotic/phenotypic). 

The Result:

This translational concept was discussed with the client, and a confidence-generating and value-optimized set of studies were chosen that are now further refined.  

We’d like to send you our company updates, invites to events and any other relevant news. By providing your details and subscribing to this list, you are giving us your consent to send you these updates.

We’ll always be mindful of how often we send our updates and you can amend your preferences at any time.

We’ll never sell or swap your data with any organisation and we’ll store your details securely, respecting your trust and privacy. Please view our privacy policy for further details.

Marketing Permissions
Please select all the ways you would like to hear from TherapeutAix:
You can unsubscribe at any time by clicking the link in the footer of our emails. For information about our privacy practices, please visit our website.